Question 2. C
In terms of Kings College Criteria there is Paracetamol and non paracetamol induced. Question doesn’t differentiate:
In non-paracetamol induced fulminant hepatic failure
•INR > 6.5 (PT > 100s) or any 3 of the following variables:
(1) age 40 yrs
(2) aetiology – non A, non B hepatitis, halothane hepatitis, idiosyncratic drug reactions
(3) duration of jaundice before encephalopathy > 7 days
(4) INR > 3.5 (PT > 50s)
(5) bilirubin > 300micromol/L
2d should be false as it is the INR that should be >6.5, not the prothrombin time…
As Richard stated, a biliribum >300 is significant in non paracetamol overdose, so 2c should be correct, or the question adjusted to state for paracetamol only.
Question 2. C
In terms of Kings College Criteria there is Paracetamol and non paracetamol induced. Question doesn’t differentiate:
In non-paracetamol induced fulminant hepatic failure
•INR > 6.5 (PT > 100s) or any 3 of the following variables:
(1) age 40 yrs
(2) aetiology – non A, non B hepatitis, halothane hepatitis, idiosyncratic drug reactions
(3) duration of jaundice before encephalopathy > 7 days
(4) INR > 3.5 (PT > 50s)
(5) bilirubin > 300micromol/L
Therefore should 2 C be true.
2d should be false as it is the INR that should be >6.5, not the prothrombin time…
As Richard stated, a biliribum >300 is significant in non paracetamol overdose, so 2c should be correct, or the question adjusted to state for paracetamol only.
Hi Chris,
Thanks for pointing this out – I have corrected he question appropriately, including Richards suggestion from a few years ago!